NKmedico

JP

ABOUT US

MISSION

Resolve the structural issues such as “increase of medical cost” or “increase of burden for elderly care” caused by average life expectancy and health expectancy gap by broadly spreading preventive medical services beginning with biomarker

VALUE

For medical professionals
Provide evidence-based clinical test services, and provide utmost support so that more people can use them
For examinees
Offer comprehensive preventive medical services including follow-up of the test service with cutting-edge technology
For researchers
Help researchers to accelerate service development and market penetration of their seeds utilizing our platform

What We provide

Test services
Provide preventive medical services through medical institutes
Approx. 1,700 medical institutes have adopted our services across Japan

Reagents for research use only
Provide LOX-index assay kit for research use only

OUR SURVICE

About stroke and heart diseases

About stroke and heart diseases

Ischemic heart disease and stroke accounted for combined 15.2 million deaths globally in 2016. These disease have remained the leading causes of deaths in the last 15 years

Mechanism of arteriosclerosis

Mechanism of arteriosclerosis
  • ・Arteriosclerosis will be progressed when lipids such as cholesterol are obtained into vascular endothelium
  • ・Accumulation of lipids in endothelial cell will lead a formation of plaque
  • ・The formation of plaque will tighten the diameter of vessels, then blood flow will get worse
  • ・The rupture of plaque will cause a thrombus and result in blood stenosis
  • ・In case blood stenosis is caused on cerebrovascular, it will develop stroke. In case on cardiovascular, it will develop heart disease

LOX-index for test services

  • ・LOX-index is a new indicator of vascular endothelial dysfunction in the early stage of arteriosclerosis, and also showing future risk of stroke or heart attack.
  • ・LOX-index is a combination assay of two biomarkers, LOX-1 and LAB.
    • >LOX-1(Lectin-like oxidized LDL receptor 1) is a scavenger receptor of oxidized or modified LDL.
    • >LAB is LOX-1 ligand containing ApoB.
  • ・Focus on the mechanism of starting point arteriosclerosis where lipids are obtained into vascular endothelium (*1)
  • ・Developed based on the cohort study where approx. 2500 subjects participated for 11 years (*2)
  • LOX-index for test services
  • LOX-index for test services

(*1) Tatsuya Sawamura et al Nature, 386:73-77, 1997.https://www.ncbi.nlm.nih.gov/pubmed/9052782
(*2) Nobutak Inoue et. al Clinical Chemistry 56:4 550-558 ,2010
https://www.ncbi.nlm.nih.gov/pubmed/20093560

LOX-index test report

  • LOX-index test report
  • LOX-index test report
  • ・Test report is composed of a comprehensive chart and an advice for improving life style

  • ・Risk is classified into 4 classes (High, moderate-high, moderate and low)

LOX-index for Research Use Only

LOX-1 ligand containing ApoB (LAB) assay kit

Kit component Description Q’ty
Microtiter Plate Coated with Recombinant human sLOX-1, 96 wells 1
Standard Lyophilized 1 vial
Enzyme Conjugate "Anti-human sLOX-1 antibody, HRP conjugated Contains non-mercury preservative" 1 vial
Substrate Solution 11mL, TMB solution 1 vial
Stop Solution 11mL, Phosphoric acid 15% 1 vial
Wash Solution 100 mL, 10X concentrated 1 vial
Diluent 50 mL 1 vial

Product number:AA0960001
Storage and stability:2℃ - 8℃ for 6months
Method:ELISA kit/Colorimetric

LOX-1

Lectin-like oxidized LDL receptor 1 (LOX-1) assay kit

Kit component Description Q’ty
Microtiter Plate Coated with Recombinant human sLOX-1, 96 wells 1
Standard Lyophilized 1 vial
Enzyme Conjugate "Anti-ApoB antibody, HRP conjugated Contains non-mercury preservative" 1 vial
Substrate Solution 11mL, TMB solution 1 vial
Stop Solution 11mL, Phosphoric acid 15% 1 vial
Wash Solution 100 mL, 10X concentrated 1 vial
Diluent 50 mL 1 vial

Product number:AA0960001
Storage and stability:2℃ - 8℃ for 6months
Method:ELISA kit/Colorimetric

Lectin-like

LOX-index assay kit (Product number: AA0960003)

LOX-index assay kit contains LAB assay kit and LOX-1 assay kit in outer box. Each kit is packed individually. The kit component of LOX-index is as same as the above mentioned assays

LOX-index assay kit

Contact us

if you would like to provide additional info, please send message to us by following e-mail address